Observations of C.S.F. flow using isotope ventriculography.

The effect of intravenous urea was discussed and the fall in pressure after the administration of the conventional dosage compared with that following 5 g. A similar reduction in pressure occurred with the smaller dose but was of shorter duration. Reductions in intracranial pressure following the use of Mannitol and Frusemide were also compared with the results seen with urea. Difficulties arose in comparing pressure changes due to those drugs in different patients under varying conditions. However, the opportunity to show the response of 40 g. urea, 250 ml. 20% Mannitol, and 30 mg. Frusemide each given intravenously to the same patient, under similar conditions, was taken. Reduction in pressure followed with each drug, the largest and most rapid fall followed the administration of urea. Duration of the response was most prolonged with Frusemide.